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KMID : 0379519990150020251
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한국독성학회지
1999 Volume.15 No. 2 p.251 ~ p.254
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Antigenicity Tests on CJ-50002 (Vibrio Vaccine)
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Kim Jong-Ho
Kang Jae-Ku
Kim Dal-Hyun
Ahn Bo-Young
Lee Na-Gyong
Lee Young-Soo
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Abstract
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In order to evaluate the antigenic potential of CJ-50002, an oral vaccine against V. vulnificus composed of whole cell lysate of V. vulnificus O-antigen serotype 4 strain, antigenicity tests were performed in guinea pigs and mouse-rat model. In active systemic anaphylaxis (ASA) test in guinea pigs, 1- and 10-times of clinical doses (50 and 500 ㎍/body, respectively) of CJ-50002 was administered per oral for 7 times in 3 weeks. But to the intravenous antigenic challenge, any anaphylactic responses were not appeared. And in passive cutaneous anaphylaxis (PCA) test using rats with mice anti-serum, 1 - and 10-times of clinical doses (4 and 40 f.19/body, respectively) of CJ-50002 was administered in mice for 7 times in 3 weeks. After we got anti-serum against CJ-50002 from the mouse blood, it was administered intradermally at the back of rats. But positive antigen-antibody reactions to the intravenous antigenic challenge were not induced. This results showed that CJ-50002 may not have antigenic potential in its clinical use.
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KEYWORD
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Antigenticity test, Active systemic anaphylaxis, Phassive cutaneous anaphylaxis, Vibrio
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